generalized epilepsy generalized epilepsy EEG vs normal EEG

The findings of this study suggest that the density and duration of epileptiform discharges can help differentiate among genetic generalized epilepsy syndromes. Generalized linear mixed models revealed that 'pure' generalized spike-wave discharges (without intervening polyspikes/polyspike waves) tended to be more frequent in absence epilepsies, although the difference was not statistically significant (P = 0.21).

The density of epileptiform discharges and the paroxysm durations were the highest in juvenile absence epilepsy followed by juvenile myoclonic epilepsy, childhood absence epilepsy, and generalized epilepsy with tonic-clonic seizures only. In the analysis of variance, six EEG variables were significantly different among syndromes: total spike density (P = 0.001), total polyspike and polyspike-wave density (P = 0.049), generalized spike-wave-only density (P < 0.001), generalized paroxysm density (P < 0.001), generalized paroxysm duration mean (P = 0.018), and generalized paroxysm duration maximum (P = 0.009). In total, 6,923 epileptiform discharges were analyzed from 105 abnormal EEGs. Although IGE has been long considered a relatively benign epilepsy. Generalized linear mixed models were also fitted to explore the association between the proportion of 'pure' generalized spike-wave paroxysms and fragments (without intervening polyspikes/polyspike-waves) and the syndromes. Idiopathic generalized epilepsy (IGE) represents a common form of epilepsy in both adult and pediatric epilepsy units. One-way analysis of variance was conducted to find out differences in EEG density scores among the syndromes. All epileptiform EEG abnormalities were quantified into density scores (total duration of epileptiform discharges per hour). Twenty-four-hour ambulatory EEGs were recorded in consecutive patients diagnosed with genetic generalized epilepsy. To evaluate EEG differences among syndromes in genetic generalized epilepsy based on quantified data.

Generalized epilepsy generalized epilepsy EEG vs normal EEG